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Published Online, 27 March 2007, www.theannals.com, DOI 10.1345/aph.1H423.
The Annals of Pharmacotherapy: Vol. 41, No. 4, pp. 674-680. DOI 10.1345/aph.1H423
© 2007 Harvey Whitney Books Company.
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L'évaluation de la causalité lors d'une interaction médicamenteuse potentielle requiert la prise en considération des propriétés des médicaments impliqués, des facteurs spécifiques au patient, et de la possible contribution des autres médicaments que le patient consomme. L'algorithme de Naranjo a été conçu pour évaluer des effets indésirables aux médicaments seulement, et non des interactions entre médicaments. Plusieurs des questions de l'algorithme de Naranjo ne s'appliquent pas aux interactions entre médicaments alors que d'autres ne spécifient pas le médicament précipitant ou le médicament affecté. Néanmoins, il a été utilisé pour évaluer des interactions entre médicaments. L'échelle de probabilité des interactions médicamenteuses (EPIM) a été développée spécifiquement pour fournir un guide à l'évaluation de causalité des interactions médicamenteuses chez un patient donné. Son utilisation a été prévue pour assister les cliniciens dans l'évaluation des effets indésirables résultant des interactions médicamenteuses potentielles. L'EPIM utilise une série de questions ayant trait à une interaction médicamenteuse potentielle pour estimer un pointage de probabilité. Une évaluation précise par le biais de l'EPIM requiert la connaissance des propriétés pharmacologiques des 2 médicaments impliqués. Une connaissance inadéquate des médicaments impliqués ou encore des mécanismes de base des interactions médicamenteuses sera une limite pour certains utilisateurs. L'EPIM peut aussi servir de guide dans la rédaction des rapports de cas signalant une interaction médicamenteuse et dans l'évaluation des rapports de cas publiés.

Marie Larouche

www.theannals.com, DOI 10.1345/aph.1H423


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This Article
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Right arrow Articles by Chan, L.-N.


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Copyright © 2007 by Harvey Whitney Books Company.