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Published Online, 13 September 2005, www.theannals.com, DOI 10.1345/aph.1G151.
 The Annals of Pharmacotherapy: Vol. 39, No. 10, pp. 1767. DOI 10.1345/aph.1G151
© 2005 Harvey Whitney Books Company.
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Cancer Chemoprevention, Volume 2: Strategies for Cancer Chemoprevention

Edited by Gary J Kelloff MD, Ernest T Hawk MD MPH, and Caroline C Sigman PhD. Published by Humana Press, Totowa, NJ, 2005. ISBN 1-58829-077-8. Clothbound, xxi + 543 pp. (28.5 x 22 cm), $175. Includes eBook/PDA on CD-ROM. www.humanapress.com

Debra K Farver, PharmD1

1 Professor of Clinical Pharmacy, College of Pharmacy, South Dakota State University, Yankton, SD

Published Online, September 13, 2005. www.theannals.com, DOI 10.1345/aph.1G151

Therapeutic Area and Audience: The authors focus on the science of chemoprevention and research of cancer chemoprevention with specific tumors. The book would ideally be placed in a medical library, drug information center, or cancer research laboratory to be used as a general reference along with Cancer Chemoprevention, Volume 1: Promising Cancer Chemopreventive Agents. Researchers and practitioners who are involved in the area of oncology will find the book beneficial.

Format and System Requirements: The 543-page hardcover book is also accompanied by a CD-ROM Value-Added eBook/PDA. The CD-ROM contains the entire volume of the book, which is licensed for only one computer or PDA. The instructions for installation (included in the book and on the CD-ROM) state that Adobe Reader 6.0 or Adobe PDA Reader software is required for the eBook, but the current edition for Adobe Reader is 7.0.

Purpose: The editors state that their intent is to provide information concerning carcinogenesis and the role of chemoprevention with medications, biologicals, or nutrients. Attention is called to the use of biomarkers, such as intraepithelial neoplasia, in the research of chemoprevention. Due to the amount of highly detailed information, those already practicing in the area of oncology would best use this book as a general reference.

Content: The book is divided into 2 parts for a total of 38 chapters. The first 5 chapters in Part I (Chemopreventive Agent Development Science) provide information concerning natural products, animal models for chemoprevention, use of transgenic mice, modeling human colorectal cancer in mice, and pathology of incipient neoplasia. The next 9 chapters discuss quantitative nuclear grade, genome database, functional genomics in breast cancer chemoprevention, proteomics, bioinformatics, models of absolute risk, genetic polymorphisms, design issues, and recruitment strategies for cancer prevention trials. Part II reviews cancer chemoprevention at major cancer target sites, which are prostate, breast, colorectal, lung, bladder, esophagus, head and neck, skin, cervix, endometrium, ovary, pancreas, liver, and multiple myeloma. Carcinogenesis and current or future chemoprevention strategies for specific tumors are evaluated in detail in the 24 chapters of Part II.

Usability: The references





This Article
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