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Published Online, 15 August 2006, www.theannals.com, DOI 10.1345/aph.1H160.
The Annals of Pharmacotherapy: Vol. 40, No. 9, pp. 1699. DOI 10.1345/aph.1H160
© 2006 Harvey Whitney Books Company.
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Pharmacotherapy: A Pathophysiologic Approach, 6th Edition

Edited by Joseph T DiPiro PharmD FCCP, Robert L Talbert PharmD FCCP BCPS, Gary C Yee PharmD FCCP, Gary R Matzke PharmD FCP FCCP, Barbara G Wells PharmD FASHP FCCP BCPP, and L Michael Posey BS Pharm. Published by McGraw-Hill Companies, Inc., New York, NY, 2005. ISBN 0-07-141613-7. Clothbound, xxxiii + 2802 pp. (28 x 22 cm), $159.95. www.pharmacotherapyonline.com

Robert J Cluxton Jr, PharmD MBA CGP

Professor of Pharmacy Practice and Family Medicine, College of Pharmacy, University of Cincinnati, Cincinnati, OH

Published Online, August 15, 2006. www.theannals.com, DOI 10.1345/aph.1H160


Therapeutic Area: Pharmacotherapy: A Pathophysiologic Approach, is a comprehensive pharmacotherapy text based on understanding disease pathophysiology and pharmacotherapy.

Audience: Educators, students, pharmacists, physicians, and other healthcare professionals are the intended audience. Both general and specialty practitioners will find this a useful reference.

Purpose: The purpose of the text is multi-factorial to: advance the quality of patient care through optimal medication management; stimulate students and encourage educators to achieve higher levels of learning; motivate practitioners to enhance the breadth, depth, and quality of care they provide; challenge established primary care providers to refine their understanding of current pharmacotherapy and to learn new concepts; and increase awareness in pharmacy and medical communities about the standards of medication therapy management

Content: Designed to be useful in entry level PharmD programs, the initial section covers basic concepts in pharmacotherapy, with the subsequent 17 sections organized by organ system disorders. There are 140 chapters, which encompass the most common medical conditions.

Usability: Chapter design elements include key concepts that are identified with numbered icons so that the reader can easily find the material of interest; clinical presentation tables of the most common signs and symptoms of diseases in typical patients; diagnostic flow diagrams, desired outcomes of treatment, dosing guidelines, monitoring approaches, and treatment algorithms; highlighted clinical controversies in treatment or patient management; abbreviations and acronyms and their meanings; and extensive current literature references, most published since 1997.

Highlights: Free with book purchase is the Pharmacotherapy eBook version and support tools at www.pharmacotherapyonline.com. The Website has learning objectives and self-assessment questions for each chapter. A companion publication, Pharmacotherapy Casebook: A Patient-Focused Approach, provides cases and questions to reinforce and expand application of pharmacotherapy principles in the text. A portable condensation of the text, Pharmacotherapy Handbook, is available for bedside use.

Limitations: Due to the depth of topic coverage, this text is not a quick reference. Nor is it a patient-centered resource that considers modification of pharmacotherapy management for those with multiple chronic disease states in various clinical settings. Because the text is written by 200 individual chapter authors, there naturally will be some variance in chapter completeness and quality. However, the section editors have attempted to reduce this variance.

Comparison with Previous Edition or Version: This sixth edition retains the disease state format used in previous editions. These sections include epidemiology, etiology, pathophysiology, clinical presentation, treatment, and evaluation of therapeutic outcomes.

Two new chapters have been added. Chapter 4, "Documentation of Pharmacy Services," will be increasingly important for pharmacists engaged in medication therapy management interventions. Chapter 87, "Solid-Organ Transplantation," combines material that was previously spread throughout several organ-specific chapters.

Comparison with Other Related Books or Products: This text remains a gold standard pharmacotherapy text. Users of the case-based approach to pharmacotherapy found in Applied Therapeutics will find that Pharmacotherapy: A Pathophysiologic Approach provides considerably more disease information, in particular the epidemiology and pathophysiology of disease. The same is true for other commonly used pharmacotherapy texts. The Textbook of Therapeutics is similar in content to Pharmacotherapy: A Pathophysiologic Approach. Both are organized by organ system diseases. However, the Textbook of Therapeutics incorporates case study materials within each chapter instead of in a separate publication. The Textbook of Therapeutics also includes a free CD-ROM version of the text.

Summary: This edition of Pharmacotherapy: A Pathophysiologic Approach is an important resource for teaching or practicing optimal pharmacotherapy. Educators and students will find it indispensable. Practitioners can rely on it as a reference and to advance their knowledge and skills. The authors have created a definitive scholarly resource designed to provide optimal pharmacotherapy.





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