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Chair and Associate Professor, Department of Fundamental and Applied Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI
Published Online, December 26, 2006. www.theannals.com, DOI 10.1345/aph.1H574
Audience: This book is intended for analytical chemists, toxicologists, or other specialists who desire a text addressing developmental and experimental issues associated with this advanced but widely accepted analytical technique. It is an excellent resource for practicing specialists who find themselves directly or indirectly associated with analytical assessment in toxicology and require a knowledge base utilizing LC/MS or LC/MS/MS. This text would be beneficial to graduate students, analytical scientists, and forensic and clinical toxicologists, as well as pharmaceutical scientists involved in analytical/toxicological assessment.
Purpose: This text serves as an authoritative resource in relating the theoretical basis and functionality of the single and multidimensional hyphenated technologies involving LC/MS along with applicability to specific areas of toxicology. As such, this text serves as a directive to the operation and appropriate selection of instrumentation relative to application requirements in analytical toxicology and related disciplines.
Content: Applications of LC-MS in Toxicology is a highly organized text, with chapter development and topic sections written in a manner that allows for clear understanding of materials presented. The organization of the text is appropriate; a discussion of such topics as theoretical basis, method development, optimization, qualitative and quantitative aspects, validation, and identification and confirmation aspects is followed by specific applications addressing therapeutic drug monitoring, drugs of abuse, small and large molecular doping drugs, as well as applications to pesticide, peptide, and contemporary challenges found in forensic chemistry. The information is current and extremely useful.
Usability: References contained in the text are current and pertinent. Those with historical basis are relevant to the material being discussed. Considering the price of today's hardbound texts, this text appears to be appropriately priced, although the text is entirely presented in monochrome with no color enhancements.
Highlights: Applications of LC-MS in Toxicology covers a wide variety of both fundamental and advanced topics within each chapter. I was pleased to discover discussions on advanced techniques and applications involving LC/MS, including ion cyclotron resonance and toxicoproteomics.
Limitations: This text does not cover application areas addressing industrial toxicology or natural product toxicants.
Comparison with Other Related Books or Products: The present text complements and supplements existing texts such as LC/MS Applications in Drug Development by MS Lee and LC/MS—A Practical User's Guide by MC McMaster.
Reviewer's Summary: Applications of LC-MS in Toxicology is an excellent text in that the editor and contributing authors have provided current information on this exciting analytical technique. The text is well written, effectively organized, and documented with current references. All chapters begin with effective introductory remarks; chapter development allows the readership to clearly comprehend the importance of information presented. All chapters follow seamlessly from one chapter to the next and contain informative supplemental tables and figures. The editor and authors achieved their purpose in publishing this specialized text. It is a recommended purchase for faculty and graduate students in analytical toxicology as well as for practicing specialists in the area of analytical, clinical, or forensic toxicology.
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