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The Annals of Pharmacotherapy: Vol. 37, No. 1, pp. 12-16. DOI 10.1345/aph.1C157
© 2003 Harvey Whitney Books Company.
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DRUG INTERACTIONS

PROPÓSITO: Investigar el riesgo de complicaciones de sangrado durante el uso combinado de los derivados de coumarin y los antiinflamatorios no esteroidales (AINE), comparado al uso de los derivados de coumarin solos.

SUJETOS Y MÉTODOS: En este estudio de un año de duración, los pacientes ambulatorios de una oficina de anticoagulación fueron observados para complicaciones de sangrado. A estos pacientes se les envió cuestionarios sobre el tipo y la consecuencia del sangrado y el uso previo de AINE. Los farmacéuticos del área identificaron aquellos pacientes que usaban derivados de coumarin y AINE concomitantemente sin problemas de sangrado. Se estimó con estos datos el riesgo relativo de sangrado por el uso combinado de derivados de coumarin y AINE.

RESULTADOS: Durante el período de un año, se identificaron 738 hemorragias en 681 usuarios de coumarin. Se detectó el uso combinado de AINE en 12.2% de estos casos. En contraste, entre la totalidad de la población de usuarios de coumarin, el 2.5% recibió prescripción por un AINE. Por lo tanto, el riesgo relativo del uso de AINE con relación a las complicaciones de sangrado fue de 5.8% (intervalo de confianza 95% 2.3–13.6).

CONCLUSIONES: El uso de AINE durante la terapia con derivados de coumarin aumenta considerablemente el riesgo de sangrado. Aunque en la práctica ambos fármacos se combinan frecuentemente, nuestros hallazgos apoyan la contraindicación al uso concomitante de ambos.




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This Article
Right arrow Abstract Freely available
Right arrow Résumé Freely available
Right arrow Full Text
Right arrow PDF
Right arrow For Our Patients
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
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Right arrow Articles Ahead of Print
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Citing Articles
Right arrow Citing Articles via HighWire
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Google Scholar
Right arrow Articles by Knijff-Dutmer, E. A.
Right arrow Articles by van de Laar, M. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Knijff-Dutmer, E. A.
Right arrow Articles by van de Laar, M. A.

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Copyright © 2003 by Harvey Whitney Books Company.