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The Annals of Pharmacotherapy: Vol. 37, No. 11, pp. 1708-1711. DOI 10.1345/aph.1D023
© 2003 Harvey Whitney Books Company.
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DRUG INFORMATION ROUNDS

OBJETIVO: Revisar el rol de alopurinol como cardioprotector durante una cirugía de puente aorto coronario (CABG por sus siglas en inglés).

EXTRACCIÓN DE DATOS: Una búsqueda en MEDLINE (1966–octubre 2002) fue realizada usando los siguientes términos: alopurinol, oxidasa de xantina, radical de oxígeno libre, y puente aorto coronario.

SELECCIÓN DE ESTUDIOS: La cantidad de citas bibliográficas recuperadas en la búsqueda con los términos: alopurinol, xantina oxidasa, y radical de oxígeno libre fueron independientemente combinadas con la cantidad de citas bibliográficas del término puente aorto coronario limitadas al lenguaje inglés y estudios en humanos. Se obtuvieron 41 citaciones, y éstas fueron evaluadas por su adaptabilidad al tópico. Trece estudios fueron encontrados adecuado con todos los resultados positivos. Cinco estudios de gran escala son discutidos.

CONCLUSIONES: Alopurinol podría reducir la incidencia de complicaciones en la cirugía de puente aorto coronario. A pesar de que la dosis óptima no ha sido determinada, la literatura revisada sugiere, al menos, que los pacientes deberían recibir alopurinol 600 mg el día antes y el día de la cirugía.




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This Article
Right arrow Abstract Freely available
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Right arrow Articles Ahead of Print
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Citing Articles
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Google Scholar
Right arrow Articles by Weimert, N. A
Right arrow Articles by Sims, J J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Weimert, N. A
Right arrow Articles by Sims, J J.

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Copyright © 2003 by Harvey Whitney Books Company.