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The Annals of Pharmacotherapy: Vol. 37, No. 2, pp. 178-181. DOI 10.1345/aph.1C203
© 2003 Harvey Whitney Books Company.
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DRUG INTERACTIONS

OBJETIVO: Este estudio se realizó para evaluar la magnitud de la interacción y relación dosis-efecto de claritromicina sobre la farmacocinética de digoxin y comparar los efectos de claritromicina con los de los inhibidores de la P-glicoproteína.

MÉTODOS: Ocho pacientes japoneses con fallo cardíaco congestivo participaron en este estudio. Todos recibieron terapia oral con digoxin por 7 días y claritromicina para tratar o prevenir pulmonía. Para evaluar el efecto de la claritromicina sobre los niveles de digoxin, se compararon los niveles de digoxin antes y después de la co-administración de claritromicina.

RESULTADOS: Los niveles de digoxin eran más altos después de la administración de claritromicina (antes, 0.838 ± 0.329 ng/mL; después, 1.36 ± 0.619 ng/mL) (p < 0.005). Se observó una correlación significativa entre la dosis de claritromicina y el incremento porcentual en la concentración de digoxin.

CONCLUSIONES: La concentración de digoxin aumenta con la co-administración de claritromicina. Este efecto demostró ser dependiente de la dosis de claritromicina. El incremento porcentual en las concentraciones de digoxin después de la dosis oral usual de claritromicina (400 mg/d) es de aproximadamente 70%. Por lo tanto, la concentración de digoxin debe vigilarse cuidadosamente durante la co-administración de claritromicina. En pacientes que reciban claritromicina conjuntamente, la dosis de digoxin puede requerir reajuste.




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This Article
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Google Scholar
Right arrow Articles by Tanaka, H.
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Right arrow Articles by Tanaka, H.
Right arrow Articles by Miyatake, K.

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Copyright © 2003 by Harvey Whitney Books Company.