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The Annals of Pharmacotherapy: Vol. 37, No. 7, pp. 1090-1099. DOI 10.1345/aph.1C351
© 2003 Harvey Whitney Books Company.
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OBJETIVO: Revisar la literatura relacionada al tratamiento de dependencia de alcohol con acamprosate, un compuesto sintético estructuralmente similar al amino ácido natural homotaurina.

FUENTES DE INFORMACIÓN: Se identificó literatura primaria y artículos de revisión con una búsqueda de MEDLINE (1966–2002). Extractos presentados en reuniones recientes también fueron revisados.

SÌNTESIS: Acamprosate está en el mercado de 24 países. Aunque el mecanismo preciso de acamprosate en el tratamiento de dependencia de alcohol no está claro, puede ser que restaure el balance entre la neurotransmisión inhibitoria y excitatoria a nivel del sistema nervioso central. Los estudios europeos han demostrado aumentos consistentes en la tasa de abstinencia comparado a placebo cuando el uso de acamprosate se pareó con terapias psicosociales y de comportamiento apropiadas. También se ha reportado disminución en los costos de salud directos e indirectos.

CONCLUSIONES: Acamprosate es un medicamento prometedor para el tratamiento de dependencia de alcohol en los Estados Unidos.





This Article
Right arrow Abstract Freely available
Right arrow Résumé Freely available
Right arrow Full Text
Right arrow PDF
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
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Right arrow [Order Reprint]
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Overman, G. P
Right arrow Articles by Guthrie, S. K
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Overman, G. P
Right arrow Articles by Guthrie, S. K

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Copyright © 2003 by Harvey Whitney Books Company.