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The Annals of Pharmacotherapy: Vol. 38, No. 1, pp. 146-150. DOI 10.1345/aph.1C391
© 2004 Harvey Whitney Books Company.
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DRUG INFORMATION ROUNDS

OBJETIVO: Evaluar el efecto antipirético de ibuprofén comparado con acetaminofén en niños con fiebre.

FUENTES DE INFORMACIÓN: Se realizó una búsqueda en MEDLINE (1966 al noviembre 2003) y EMBASE (1998 al noviembre 2003) utilizando los términos de búsqueda ibuprofén y acetaminofén y la bibliografía de artículos seleccionados.

SÍNTESIS: Ibuprofén es significativamente más efectivo que acetaminofén en reducir la fiebre luego de 1 dosis. Se encontró que ibuprofén fue más efectivo luego de 6 horas, pero no después de un período mayor de tiempo. Estudios con dosis múltiples tampoco han demostrado que un fármaco es mejor que el otro.

CONCLUSIONES: La eficacia y efectividad de acetaminofén e ibuprofén en sus dosis recomendadas es similar, con un efecto beneficioso un poco mayor con ibuprofén.




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This Article
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Copyright © 2004 by Harvey Whitney Books Company.