The Annals Holiday Offer - Save 50%
home help contact us subscription past issues search current issue
QUICK SEARCH:   [advanced]


     


Published Online, 24 August 2004, www.theannals.com, DOI 10.1345/aph.1E068.
 The Annals of Pharmacotherapy: Vol. 38, No. 10, pp. 1631-1634. DOI 10.1345/aph.1E068
© 2004 Harvey Whitney Books Company.
This Article
Right arrow Abstract Freely available
Right arrow Résumé Freely available
Right arrow Full Text
Right arrow PDF
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Articles Ahead of Print
Right arrow [Order Reprint]
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Summers, M. A
Right arrow Articles by McAuley, J. W
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Summers, M. A
Right arrow Articles by McAuley, J. W

OBJETIVO: La sobreexpresión de glucoproteína-P en el sistema nervioso central puede ser un mecanismo de farmacoresistencia en pacientes con epilepsia. El calcio antagonista, verapamil, es un inhibidor conocido de glucoproteína-P, de drogas anticonvulsivantes del cerebro. Este bloqueo elevaría la concentración intracelular de las drogas anticonvulsivantes y últimamente disminuiría las convulsiones en pacientes con epilepsia refractaria.

RESUMEN DEL CASO: Después de la adición de verapamil al régimen antiepiléptico de una paciente de 24 años de edad con epilepsia refractaria, aumentó al doble el tiempo promedio entre sus hospitalizaciones para convulsiones parciales con sintomatología compleja. La adición de verapamil mejoró significativamente el control de las convulsiones y la calidad de vida en esta paciente con epilepsia farmacoresistente.

DISCUSIÓN: Después de la adición de verapamil al régimen antiepiléptico, aumentó al doble el tiempo promedio entre hospitalizaciones para convulsiones parciales con sintomatología compleja.

CONCLUSIONES: El verampamil ofece a los pacientes con epilepsia resistente a los medicamentos la esperanza de mejoramiento en el control de las convulsiones gracias a su posible efecto inhibitorio sobre la glucoproteína-P.

www.theannals.com, DOI 10.1345/aph.1E068


This article has been cited by other articles:


Home page
 Mol. Pharmacol.Home page
R. W. Robey, A. Lazarowski, and S. E. Bates
P-Glycoprotein--a Clinical Target in Drug-Refractory Epilepsy?
Mol. Pharmacol., May 1, 2008; 73(5): 1343 - 1346.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
E. A. van Vliet, R. van Schaik, P. M. Edelbroek, R. A. Voskuyl, S. Redeker, E. Aronica, W. J. Wadman, and J. A. Gorter
Region-Specific Overexpression of P-glycoprotein at the Blood-Brain Barrier Affects Brain Uptake of Phenytoin in Epileptic Rats
J. Pharmacol. Exp. Ther., July 1, 2007; 322(1): 141 - 147.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
R. Clinckers, I. Smolders, A. Meurs, G. Ebinger, and Y. Michotte
Quantitative in Vivo Microdialysis Study on the Influence of Multidrug Transporters on the Blood-Brain Barrier Passage of Oxcarbazepine: Concomitant Use of Hippocampal Monoamines as Pharmacodynamic Markers for the Anticonvulsant Activity
J. Pharmacol. Exp. Ther., August 1, 2005; 314(2): 725 - 731.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
H. A. Volk and W. Loscher
Multidrug resistance in epilepsy: rats with drug-resistant seizures exhibit enhanced brain expression of P-glycoprotein compared with rats with drug-responsive seizures
Brain, June 1, 2005; 128(6): 1358 - 1368.
[Abstract] [Full Text] [PDF]

This Article
Right arrow Abstract Freely available
Right arrow Résumé Freely available
Right arrow Full Text
Right arrow PDF
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Articles Ahead of Print
Right arrow [Order Reprint]
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Summers, M. A
Right arrow Articles by McAuley, J. W
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Summers, M. A
Right arrow Articles by McAuley, J. W

homecopy help contact us subscription past issues search current issue
Copyright © 2004 by Harvey Whitney Books Company.