The Annals Holiday Offer - Save 50%
home help contact us subscription past issues search current issue
QUICK SEARCH:   [advanced]


     


Published Online, 30 January 2004, www.theannals.com, DOI 10.1345/aph.1D128.
 The Annals of Pharmacotherapy: Vol. 38, No. 3, pp. 414-417. DOI 10.1345/aph.1D128
© 2004 Harvey Whitney Books Company.
This Article
Right arrow Abstract Freely available
Right arrow Résumé Freely available
Right arrow Full Text
Right arrow PDF
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Articles Ahead of Print
Right arrow [Order Reprint]
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Prats, C. H.
Right arrow Articles by Baines, J. P. O.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Prats, C. H.
Right arrow Articles by Baines, J. P. O.

OBJETIVO: Describir el primer caso de queratitis postraumática por Scedosporium apiospermum (ScA) tratada con éxito con voriconazol sistémico y tópico.

RESUMEN DEL CASO: Varón de 19 años que acude a nuestro hospital con herida incisa en ojo izquierdo y córnea totalmente seccionada. El accidente se produjo con un cúter que era utilizado habitualmente en labores de jardinería. Tras el tratamiento empírico inicial, el paciente recibió voriconazol sistémico y tópico lo que evitó la enucleación del ojo. Transcurridos aproximadamente 5 meses desde el accidente, se practicó queratoplastia, extracción de catarata postraumática, e implantación de lente intraocular con evolución clínica favorable.

DISCUSIÓN: A pesar de que la queratitis por ScA es poco frecuente, debe sospecharse siempre que exista historia de daño ocular con objetos sucios y contaminados. Entre los antifúngicos disponibles, voriconazol muestra ventajas importantes como son la disponibilidad de una formulación oral y menor CMI para este patógeno.

CONCLUSIONES: Voriconazol se presenta como una excelente alternativa en el tratamiento de la queratitis por ScA. Tiene la ventaja añadida de disponer de formulación oral lo cual es de vital importancia ante la larga duración de los tratamientos en este tipo de infecciones.

www.theannals.com, DOI 10.1345/aph.1D128


This article has been cited by other articles:


Home page
 The Annals of PharmacotherapyHome page
D. Al-Badriyeh, L. Leung, G. E Davies, K. Stewart, and D. Kong
Successful Salvage Treatment of Scedosporium apiospermum Keratitis with Topical Voriconazole After Failure of Natamycin
Ann. Pharmacother., June 1, 2009; 43(6): 1139 - 1142.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
A. Dupuis, N. Tournier, G. Le Moal, and N. Venisse
Preparation and Stability of Voriconazole Eye Drop Solution
Antimicrob. Agents Chemother., February 1, 2009; 53(2): 798 - 799.
[Abstract] [Full Text] [PDF]

Home page
 Br J OphthalmolHome page
S M Hariprasad, W F Mieler, T K Lin, W E Sponsel, and J R Graybill
Voriconazole in the treatment of fungal eye infections: a review of current literature
Br J Ophthalmol, July 1, 2008; 92(7): 871 - 878.
[Abstract] [Full Text] [PDF]

Home page
 Arch OphthalmolHome page
D. Lau, M. Fedinands, L. Leung, R. Fullinfaw, D. Kong, G. Davies, and M. Daniell
Penetration of Voriconazole, 1%, Eyedrops Into Human Aqueous Humor: A Prospective Open-Label Study
Arch Ophthalmol, March 1, 2008; 126(3): 343 - 346.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Microbiol. Rev.Home page
K. J. Cortez, E. Roilides, F. Quiroz-Telles, J. Meletiadis, C. Antachopoulos, T. Knudsen, W. Buchanan, J. Milanovich, D. A. Sutton, A. Fothergill, et al.
Infections Caused by Scedosporium spp.
Clin. Microbiol. Rev., January 1, 2008; 21(1): 157 - 197.
[Abstract] [Full Text] [PDF]

Home page
 Arch OphthalmolHome page
P. Lalitha, B. L. Shapiro, M. Srinivasan, N. V. Prajna, N. R. Acharya, A. W. Fothergill, J. Ruiz, J. D. Chidambaram, K. J. Maxey, K. C. Hong, et al.
Antimicrobial Susceptibility of Fusarium, Aspergillus, and Other Filamentous Fungi Isolated From Keratitis
Arch Ophthalmol, June 1, 2007; 125(6): 789 - 793.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
M. A. Thiel, A. S. Zinkernagel, J. Burhenne, C. Kaufmann, and W. E. Haefeli
Voriconazole Concentration in Human Aqueous Humor and Plasma during Topical or Combined Topical and Systemic Administration for Fungal Keratitis
Antimicrob. Agents Chemother., January 1, 2007; 51(1): 239 - 244.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
K. C. Klein and R. A. Blackwood
Topical Voriconazole Solution for Cutaneous Aspergillosis in a Pediatric Patient After Bone Marrow Transplant
Pediatrics, August 1, 2006; 118(2): e506 - e508.
[Abstract] [Full Text] [PDF]

This Article
Right arrow Abstract Freely available
Right arrow Résumé Freely available
Right arrow Full Text
Right arrow PDF
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Articles Ahead of Print
Right arrow [Order Reprint]
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Prats, C. H.
Right arrow Articles by Baines, J. P. O.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Prats, C. H.
Right arrow Articles by Baines, J. P. O.

homecopy help contact us subscription past issues search current issue
Copyright © 2004 by Harvey Whitney Books Company.