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Published Online, 15 March 2005, www.theannals.com, DOI 10.1345/aph.1E228.
 The Annals of Pharmacotherapy: Vol. 39, No. 5, pp. 913-917. DOI 10.1345/aph.1E228
© 2005 Harvey Whitney Books Company.
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DRUG INFORMATION ROUNDS

OBJETIVO: Evaluar el papel del óxido nítrico inhalado (ONi) en receptores de trasplantes de corazón o pulmón.

FUENTES DE INFORMACIÓN: Literatura científica identificada por medio de una búsqueda en MEDLINE (de 1966 a julio de 2004).

SÍNTESIS: La hipertensión pulmonar causada por insuficiencia ventricular derecha o por lesiones de reperfusión isquémica son, respectivamente, complicaciones que surgen después de un trasplante de corazón o de pulmón. Esta revisión de 7 estudios publicados analiza el papel del ONi en estas poblaciones y ofrece recomendaciones de tratamiento, dosificación y monitorización basadas en pruebas.

CONCLUSIONES: El ONi muestra beneficios hemodinámicos en pacientes con trasplante de corazón recién operados que padecen hipertensión pulmonar preexistente; también proporciona beneficios hemodinámicos variables en receptores de trasplante de pulmón. Actualmente, los datos de morbilidad y mortalidad no favorecen ninguna de las dos indicaciones. Su uso es meramente de apoyo y requiere estudios adicionales.

www.theannals.com, DOI 10.1345/aph.1E228


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This Article
Right arrow Abstract Freely available
Right arrow Résumé Freely available
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Citing Articles
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Google Scholar
Right arrow Articles by Rea, R. S
Right arrow Articles by Seybert, A. L
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PubMed
Right arrow PubMed Citation
Right arrow Articles by Rea, R. S
Right arrow Articles by Seybert, A. L

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