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Published Online, 28 February 2006, www.theannals.com, DOI 10.1345/aph.1G533.
 The Annals of Pharmacotherapy: Vol. 40, No. 3, pp. 550-552. DOI 10.1345/aph.1G533
© 2006 Harvey Whitney Books Company.
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El Estudio de Fallo Cardíaco en Africano Americanos (A-HeFT, por sus siglas en inglés) demostró que isosorbide/hidralazina fue asociado con reducciones significativas en mortalidad y en Africano Americanos con fallo cardíaco comparado con placebo. Los resultados de un subestudio publicado recientemente identificaron una variante del gen relacionado con la producción de óxido nítrico sintasa, a la que se atribuye la respuesta al tratamiento observada en pacientes participantes en el A-HeFT. Este hallazgo sugiere que la habilidad de isosorbide/hidralazina para mejorar el descenlace del fallo cardíaco está atada a una característica genética que puede ser más prevaleciente en Africano Americanos que en blanco personas, pero no necesariamente está relacionada a la raza según autopercibida.

www.theannals.com, DOI 10.1345/aph.1G533



This Article
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Copyright © 2006 by Harvey Whitney Books Company.