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Published Online, 11 July 2006, www.theannals.com, DOI 10.1345/aph.1G645.
 The Annals of Pharmacotherapy: Vol. 40, No. 9, pp. 1635-1639. DOI 10.1345/aph.1G645
© 2006 Harvey Whitney Books Company.
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DRUG INFORMATION ROUNDS

OBJETIVO: Evaluar la efectividad y seguridad de dosis reducidas de la vacuna de influenza trivalente inactivada en adultos.

FUENTES DE INFORMACIÓN: Se realizó una búsqueda de la literatura en el sistema MEDLINE (1966-mayo 2006). Se utilizaron palabras claves como: inactivado, trivalente, vacuna de influenza, dosis e intradermal.

SÍNTESIS: Cuatro estudios publicados recientemente evaluaron la seguridad y efectividad de dosis reducidas de la vacuna de influenza trivalente inactivada. Dosis reducidas mostraron tener inmunogenicidad similar comparado con dosis estándar de la vacuna en individuos saludables menores de 60 años de edad. La administración intramuscular causó menos efectos secundarios locales comparados con otras rutas de administración de la vacuna y las dosis utilizadas en estos estudios limitan la comparación de sus resultados.

CONCLUSIONES: Los Centros para el Control y la Prevención de Enfermedades no recomiendan vacunar con dosis reducidas de la vacuna de influenza. Si la vacunación con dosis reducidas se va ha utilizar en tiempos de escasez de la vacuna, se debe administrar únicamente a adultos saludables menores de 60 años de edad y se prefiere la ruta intramuscular.

www.theannals.com, DOI 10.1345/aph.1G645


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This Article
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Right arrow Articles by Wyatt, K. N
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Copyright © 2006 by Harvey Whitney Books Company.