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Published Online, 27 March 2007, www.theannals.com, DOI 10.1345/aph.1H423.
 The Annals of Pharmacotherapy: Vol. 41, No. 4, pp. 674-680. DOI 10.1345/aph.1H423
© 2007 Harvey Whitney Books Company.
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La evaluación de las causas para las interacciones potenciales entre fármacos requiere una evaluación cuidadosa de las propiedades tanto del fármaco precipitante como del fármaco afectado, y la posible contribución de otros fármacos que el paciente pudiera estar utilizando. El nomograma de Naranjo fue diseñado para evaluar eventos adversos relacionados al uso de fármacos en individuos, no interacciones entre varios fármacos. Algunas de las preguntas del nomograma de Naranjo no aplican a interacciones potenciales entre fármacos mientras otras no distinguen entre el fármaco precipitante y el afectado. Sin embargo, el instrumento ha sido utilizado para evaluar interacciones entre fármacos. La Escala de Probabilidad de Interacciones entre Fármacos (EPIF, DIPS) fue desarrollada específicamente para proveer una guía para evaluar las causas de una interacción entre fármacos en un paciente específico. La intención es que se utilice el instrumento para asistir al personal clínico en la evaluación de los efectos adversos relacionados a las interacciones entre drogas. La EPIF utiliza una serie de preguntas relacionadas al potencial de interacción para estimar una puntuación de probabilidad. Una evaluación certera utilizando el instrumento requiere conocimiento de las propiedades farmacológicas tanto del fármaco precipitante como del afectado. Un conocimiento inadecuado tanto de los fármacos en consideración como de los mecanismos básicos de interacciones entre drogas sería una limitación para algunos usuarios. La Escala de Probabilidad de Interacciones entre Fármacos también puede servir como guía en la preparación de publicaciones sobre casos de interacciones entre fármacos y en la evaluación de casos que hayan sido publicados.

Mitchell Nazario

www.theannals.com, DOI 10.1345/aph.1H423


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This Article
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Copyright © 2007 by Harvey Whitney Books Company.